On Basic Requirements to Main Elements of Laser Correlation Spectrometer
https://doi.org/10.32603/1993-8985-2020-23-1-83-95
Abstract
Introduction. Laser correlation spectroscopy is a promising method that allows one to analyze sizes of nanoparticles and to evaluate their shape and dynamics of aggregation in liquids. A limited usage of laser correlation spectroscopy is currently caused by insufficient accuracy of existing instruments and data processing algorithms. The paper described the development of laser correlation spectroscopic hardware complex designed for nanoparticles size determination in liquids. The basic requirements for the elements of the device and the approaches used to calculate the signal-to-noise ratio were discussed. The achieved parameters of the laser correlation spectrometer were presented.
Aim. To develop the hardware for nanoparticles size determination in liquids and to optimize the parameters of hardware elements to increase signal-to-noise ratio.
Materials and methods. Theory of dynamic light scattering to describe scattering of laser radiation in liquids was applied. Fundamental requirements for the elements of the laser correlation spectrometer were described.
Results. An original scheme of the laser correlation spectrometer was developed, the basic requirements for the general scheme elements were described. Equations for calculating signal-to-noise ratio were given.
Conclusion. The analysis of the main parameters of the elements of the laser correlation spectroscopic scheme were carried out. It helps one to evaluate the expected signal-to-noise ratio in laser correlation spectrometers.
Keywords
About the Authors
E. N. VelichkoRussian Federation
Elena N. Velichko, Cand. Sci. (Eng.) (29.09.2010), Associate Professor, Director of the Higher School of Applied Physics and Space Technology, Institute of Physics, Nanotechnology and Telecommunications
The author of more than 150 scientific publications. Area of expertise: optics, laser physics, biophotonics.
29 Polytechnicheskaya Str., St.Petersburg 195251
O. I. Kotov
Russian Federation
Oleg I. Kotov, Dr. Sci. (Phys.-Math.) (1995), Professor of the Higher School of Applied Physics and Space Technologies, Institute of Physics, Nanotechnology and Telecommunications
The author of more than 100 scientific publications. Area of expertise: radiophysics and optical measurement methods.
29 Polytechnicheskaya Str., St.Petersburg 195251
E. K. Nepomnyashchaya
Russian Federation
Elina K. Nepomnyashchaya, Engineer of the Higher School of Applied Physics and Space Technologies, Institute of Physics, Nanotechnology and Telecommunications
The author of 59 scientific publications. Area of expertise: optical measurement methods, biomedical sensors.
29 Polytechnicheskaya Str., St.Petersburg 195251
A. N. Petrov
Russian Federation
Aleksey N. Petrov, Postgraduate student at the Higher School of Applied Physics and Space Technology, Institute of Physics, Nanotechnology and Telecommunications
The author of 10 scientific publications. Area of expertise: radio physics, optical measurements, radio over fiber systems, radio photonics.
29 Polytechnicheskaya Str., St.Petersburg 195251
A. V. Sokolov
Russian Federation
Alexander V. Sokolov, Cand. Sci. (Eng.) (2003), Deputy Director
The author of more than 30 scientific publications. Area of expertise: optics, optoelectronics, navigation systems.
30 Malaya Posadskaya Str., St Petersburg 197046
References
1. Toropova Y. G., Pechnikova N. A., Zelinskaya I. A., Korolev D. V., Gareev K. G., Markitantova A. S., Bogushevskaya V. D., Povolotskaya A. V., Manshina A. A. Hemocompatibility of Magnetic Magnethite Nanoparticles and Magnetite-Silica Composites in Vitro. Bull. Sib. Med. 2018, vol. 17, pp. 157–167. doi: 10.20538/1682- 0363-2018-3-157-167
2. Fischer K., Schmidt M. Pitfalls and Novel Applications of Particle Sizing by Dynamic Light Scattering. Biomaterials. 2016, vol. 98, pp. 79–91. doi: 10.1016/j.biomaterials.2016.05.003
3. Mishra I., Patel V., Robinson M., Gordon K. Dynamics Light Scattering as a Tool for Assessing Health Status and Disease Risk. Biophysical J. 2016, vol. 110, no. 3, pp. 476a. doi: 10.1016/j.bpj.2015.11.2547
4. Li C., Ma J., Fan Q., Tao Y., Li G. Dynamic Light Scattering (DLS)-Based Immunoassay for Ultra-Sensitive Detection of Tumor Marker Protein. Chemical Communications. 2016, vol. 52, no. 50, pp. 7850–7853. doi: 10.1039/C6CC02633H
5. Grebenikova N. M., Smirnov K. J., Davydov V. V., Rud V. Y., Artemiev V. V. Features of Monitoring the State of the Liquid Medium by Refractometer. J. Phys. Conf. Ser. 2018, vol. 1135, conf. 1, 5 p. doi: 10.1088/1742-6596/1135/1/012055
6. Grebenikova N. M., Myazin N. S., Rud V. Y., Davydov R. V. Monitoring of Flowing Media State by Refraction Phenomenon. Proc. 2018 IEEE Int. Conf. Electr. Eng. Photonics. 22–23 Okt. 2018, St. Petersburg. P. 295–297. doi: 10.1109/EExPolytech.2018.8564409
7. Ulyanov S. S. Speckle Dynamics and the Doppler Effect. Soros Educational Journal. 2001, vol. 7, no. 10, pp. 109–114 (In Russ.)
8. Cummins H. Z. Light beating spectroscopy. Photon correlation and light beating spectroscopy. Boston, Springer, 1974, pp. 225–236.
9. Yumozhapova N. V., Arkhincheev V. E. Effective Diffusion Equations of Fractional Order: Generalized Fik of Law and Asymptotic Solutions. Vestnik Byriatskogo gosudarstvennogo universiteta. 2012, no. 3, pp. 178–185. (In Russ.)
10. Koppel D. E. Analysis of Macromolecular Polydispersity in Intensity Correlation Spectroscopy: the Method of Cumulants. The J. of Chemical Physics. 1972, vol. 57, no. 11, pp. 4814–4821.
11. Nepomnyashchaya E. Optical Properties of Biomolecular Complexes. Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine. Intern. Society for Optics and Photonics, 2019, vol. 11065, pp. 110651T. doi: 10.1117/12.2523342
12. Kostromitin A. O., Kudryashov A. V., Liokumovich L. B. Measurement and Analysis of Modulation and Noise in the Output Frequency of Single-Frequency Semiconductor Diode Lasers. J. of Applied Spectroscopy. 2015, vol. 82, no. 4, pp. 659–664. doi: 10.1007/s10812-015-0159-z
13. Kostromitin A. O., Skliarov P. V., Liokumovich L. B., Ushakov N. A. Laser Frequency Noise Measurement by Forming an Interference Signal with Subcarrier Frequency. 2019 IEEE Intern. Conf. on Electrical Engineering and Photonics (EExPolytech). 17–18 Okt. 2019, St. Petersburg, pp. 336–338. doi: 10.1109/EExPolytech.2019.8906857
14. Available at: https://www.eagleyard.com/fileadmin/ downloads/data_sheets/EYP-DBR-0633-00005-2000-BFY02- 0000.pdf (accessed 26.02.2020).
15. Akhmanov S. A., D'yakov Yu. E., Chirkin A. S. Introduction to Statistical Radiophysics and Optics. Moscow, Science. 1981, 640 p. (In Russ.)
16. Tikhonov V. I. Statistical radio engineering. Moscow, Ripol Classic, 2013, 684 p. (In Russ.)
17. The state standard of January 1, no. GOST P 8.774-2011. The Dispersed Composition of Liquid Media. Determination of Particle Sizes by Dynamic Light Scattering. Moscow, Standartinform, 2019, 12 p. (In Russ.)
18. Kwon S. Y., Kim Y-G., Lee S. H., Moon J. H. Uncertainty Analysis of Measurements of the Size of Nanoparticles in Aqueous Solutions using Dynamic Light Scattering. Metrologia. 2011, vol. 48, no. 5, pp. 417–425. doi: 10.1088/0026-1394/48/5/024
19. Freeman R. L. Fiber-Optic Systems for TelecomMunications. New York, Wiley-Interscience, 2002, 416 p.
20. Asayonak M. A., Zenevich A. O. Investigation of the Characteristics of Silicon Photomultipliers. Applied Physics. 2018, vol. 6, pp. 49–53. (In Russ.)
21. Petrova G. P., Petrusevich Yu. M., Evseevicheva A. N. Molecular Clusters in Water Protein Solutions in the Presence of Heavy Metal Ions. J. Gen Physiol Biophys. 1998, vol. 17, no. 2, pp. 97–104.
22. Minton A. P. Static Light Scattering from Concentrated Protein Solutions. I: General Theory for Protein Mixtures and Application to Self-Associating Proteins. J. Biophys. 2007, vol. 93, no. 4, pp. 1321–1328.
23. Nepomnyashchaya E., Antonova E. Methods and Algorithms for Numerical Calculations in Dynamic Light Scattering Problems // 2018 IEEE Intern. Conf. on Electrical Engineering and Photonics (EExPolytech). 22–23 Okt. 2018, St. Petersburg, pp. 136–140. doi: 10.1109/EExPolytech.2018.8564438
Review
For citations:
Velichko E.N., Kotov O.I., Nepomnyashchaya E.K., Petrov A.N., Sokolov A.V. On Basic Requirements to Main Elements of Laser Correlation Spectrometer. Journal of the Russian Universities. Radioelectronics. 2020;23(1):83-95. (In Russ.) https://doi.org/10.32603/1993-8985-2020-23-1-83-95